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How to use BYDUREON

Your healthcare provider should show you how to use BYDUREON before you use it for the first time. Then, when you are ready to administer BYDUREON yourself, the information in this section will help you.

Before preparing and injecting BYDUREON, first read the Instructions for Use. This is a step-by-step guide that comes with your prescription and includes easy-to-follow pictures of the process. Follow the instructions completely and carefully each time you use BYDUREON. You may also download the Instructions for Use here.

Instructions for Use (PDF)

You will find instructions for the BYDUREON Single-dose Pen on page 52 and instructions for the Single-dose Tray on page 34.

We also recommend that you view the videos below before using the BYDUREON Single-dose Pen or BYDUREON Single-dose Tray.

BYDUREON Step-by-Step Demonstration Videos

Watch a step-by-step video on how to use the BYDUREON Single-dose Pen

Watch a step-by-step video on how to use the BYDUREON Single-dose Pen

BYDUREON Single-Dose Pen Video

BYDUREON Single-dose Tray

Watch a step-by-step video on how to use the BYDUREON single-dose Tray

BYDUREON Single-Dose Tray Video

Explore this information to learn more about where and when to use BYDUREON. You can also learn about proper storage and disposal. If at any time you have questions about your BYDUREON treatment, talk to your healthcare provider. For assistance, you may also call a BYDUREON Care Partner toll-free at 1-844-929-3736.

Learn More About Where and When to Use BYDUREON

Where to inject BYDUREON

Please note that BYDUREON must be injected right after you mix it.

  • Inject BYDUREON under the skin (subcutaneously), not into a muscle or vein, exactly the way your healthcare provider instructed you to. You can do the injection in your stomach area (abdomen), your thigh, or the back of your upper arms

  • After injecting with the BYDUREON Single-dose Pen, make sure you hold the needle in your skin for 10 seconds to get the full dose

  • Each week you can use the same general area of your body. Just be sure not to inject in the exact same place

About injection site bumps

After injecting BYDUREON, you may see or feel a small, raised bump at the injection site within 2-4 weeks (see visual below). This is your body reacting to the microspheres that hold the medicine as it works to dissolve them. These bumps rarely need medical attention, and do not interfere with BYDUREON treatment. They generally go away within 3 to 6 weeks.

But keep in mind that these more common bumps are different from serious injection-site reactions that may include severe pain, swelling, blisters, an open wound, or a dark scab at the injection site. Some of these injection-site reactions have required surgical intervention. Call your healthcare provider right away if you experience any of these reactions.

Where to inject BYDUREON

When to inject BYDUREON

  • BYDUREON should be used once every 7 days

  • Take BYDUREON on the same day each week

  • You can take BYDUREON any time of the day, with or without meals

Choosing your dosing day

You can choose to inject your first dose on any day of the week. Then, you’ll need to inject it on the same day each week. This is your "dosing day." You can inject BYDUREON at any time during your dosing day, with or without food.

Try to select a day that best fits into your weekly schedule and is easy to remember. It can help to choose a dosing day and time that is linked to a regular weekly activity. For example, if you have a favorite TV show you watch on Friday nights, you could plan to inject your BYDUREON dose on Friday nights.

Changing your dosing day

If you want to change your dosing day, you can. When changing the dosing day, you can choose any day you want; however, the next dose must be injected at least 3 days after the previous dose. Do not inject 2 doses of BYDUREON less than 3 days apart.

For instance, if you wanted to change your dosing day from Friday to Sunday, you would:

  • Inject your dose of BYDUREON on Friday

  • Wait 7 days until the following Friday

  • Inject your dose again two days later on Sunday

  • Continue to inject your dose of BYDUREON every Sunday after that

When to inject BYDUREON

Once you’ve selected a dosing day that works for you, try to stay with it. It’s not a good idea to change your dosing day often.

Missing an injection

If you miss an injection of BYDUREON on your dosing day, give yourself an injection as soon as you can, unless your next dosing day is 1 or 2 days away. In that case, wait until your next regular dosing day, and inject your dose on that day. Don’t inject 2 doses less than 3 days apart.

How to store BYDUREON


It is important that you carefully follow all storage instructions for BYDUREON.

  • BYDUREON should be stored in your refrigerator at 36°F to 46°F (2°C to 8°C) and protected from light until prepared for use

  • Do not freeze BYDUREON. Do not use BYDUREON if it has been frozen. Do not use BYDUREON past the expiration date

  • Keep BYDUREON, and all medicine, out of reach of children

  • If needed, you can keep the BYDUREON single-dose tray and the single-dose pen out of the refrigerator at 68°F to 77°F (20°C to 25°C) for up to 4 weeks

Disposal instructions

Proper disposal of needles is important for your safety and the safety of those around you.

    How to store BYDUREON
  • Use a biohazard container made specifically for disposing of used injection devices (called a “sharps” container) or a puncture-resistant container to throw out the device with the needle still attached. To avoid a needlestick injury, do not put the cover back on the needle

  • Throw away all other parts in the trash. You do not have to save them

  • Check with your healthcare provider or pharmacist for instructions about the right way to dispose of used injection devices. There may be special local or state laws about how to dispose of used injection devices and/or puncture-resistant containers

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