Taking Control Begins With Knowing What to Expect

Congratulations! You have been taking BYDUREON BCise for weeks and trying to do your best to continue to eat healthy and exercise. If you don’t see noticeable results in your blood sugar numbers right away, don’t worry; this does not mean that BYDUREON BCise is not working.

How long does it take for BYDUREON BCise to work?

BYDUREON BCise works gradually and continually. That takes time, but it is worth it. As you continue to take your weekly doses, the amount of medicine in your body gradually builds up over 10 weeks until it reaches an optimal level to work in your body. With continued once-weekly dosing, the extended-release delivery system of BYDUREON BCise keeps a consistent level of medicine in your body, ready to work when you need it to help lower your blood sugar.

Remember, you need to continue to take BYDUREON BCise exactly as your doctor or healthcare provider has prescribed it, along with continuing to follow the treatment plan they’ve recommended.

This graph is a simplified representation of how the medicine builds up in your body, and the levels of medicine in your blood may not represent actual changes in your blood sugar.

About injection site bumps

Some people taking BYDUREON BCise can get a small raised bump under their skin. This is a normal body response to the tiny beads in BYDUREON BCise that slowly release medicine over time, and the bump usually disappeared in an average of 4 weeks in BYDUREON clinical studies.

Serious injection site reactions, with or without bumps, have happened in some people who use BYDUREON BCise. If you have any symptoms of an injection site reaction, call your doctor or healthcare provider. Symptoms include severe pain, swelling, blisters, an open wound and/or a dark scab.

Other Side Effects

Nausea is a common side effect when you first start using BYDUREON BCise. It usually decreases over time in most people as their body gets used to the medicine.

The illustration here shows an average bump size. The image is based on healthcare providers’ descriptions from BYDUREON clinical studies.

Learn About Testing A1C

Your A1C level is an important indicator of your blood sugar control.

Find Out How

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BYDUREON BCise may cause serious side effects, including:

  • POSSIBLE THYROID TUMORS, INCLUDING CANCER Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In animal studies, BYDUREON and medicines that work like it caused thyroid tumors, including thyroid cancer. It is not known if BYDUREON BCise will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

  • Do not use BYDUREON BCise if you or any of your family members have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

  • Do not use BYDUREON BCise if you have had an allergic reaction to exenatide or any of the other ingredients in BYDUREON BCise

  • Inflammation of the pancreas (pancreatitis) Stop using BYDUREON BCise and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back

  • Low blood sugar (hypoglycemia) Your risk for getting low blood sugar may be higher if you use BYDUREON BCise with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Tell your healthcare provider if you take other diabetes medicines. Talk to your healthcare provider about managing low blood sugar. Signs and symptoms of low blood sugar include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness, or feeling jittery

  • Kidney problems (kidney failure) Tell your healthcare provider if you have or had kidney problems. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse

  • Stomach problems Tell your healthcare provider if you have severe stomach problems, such as slowed emptying of your stomach (gastroparesis) or problems digesting food. Other medicines like BYDUREON BCise may cause severe stomach problems. It is not known if BYDUREON BCise causes or worsens stomach problems

  • Serious allergic reactions Stop using BYDUREON BCise and get medical help right away if you have any symptoms of a serious allergic reaction, including itching, rash, or difficulty breathing

  • Injection-site reactions Serious injection-site reactions, with or without bumps (nodules), have happened in some people who use BYDUREON. Some of these injection-site reactions have required surgery. Call your healthcare provider if you have any symptoms of injection-site reactions, including severe pain, swelling, blisters, an open wound, or a dark scab

The most common side effects with BYDUREON BCise may include a bump at the injection site and/or nausea. Nausea is most common when you first start using BYDUREON BCise, but decreases over time in most people as their body gets used to the medicine.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, as taking them with BYDUREON may affect how each medicine works.

Before using BYDUREON BCise, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant or nurse. BYDUREON BCise may harm your unborn baby.


  • BYDUREON BCise is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise

  • BYDUREON BCise is not recommended as the first choice of medicine for treating diabetes

  • BYDUREON BCise is not a substitute for insulin and is not for people with type 1 diabetes or people with diabetic ketoacidosis

  • Do not use BYDUREON, BYDUREON BCise, BYETTA or other medicines containing exenatide together

  • It is not known if BYDUREON BCise can be used in people with a history of pancreatitis

Please click here for Medication Guide, and click here for Full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.