To help lower blood sugar in adults with type 2 diabetes along with diet and exercise who are not at goal with pills

“*BYDUREON IS ON IT…HELPING YOU ALL WEEK WHEN YOU NEED IT.”*

Individual results may vary.

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HOW BYDUREON WORKS

BYDUREON responds when your blood sugar levels change.

BYDUREON is the only once-weekly treatment of its kind with a unique continuous-release delivery system that gradually releases the medicine (exenatide) from tiny particles called microspheres.

One dose lasts 7 days, so you have to take it once a week.

BYDUREON is not insulin. BYDUREON is a medicine that works by helping your body release its own insulin when needed to reduce blood sugar. It’s ON IT, helping when you need it—all week long.

THINK OF IT AS PART OF YOUR ROUTINE

With BYDUREON, you only take one dose, once a week, so it may just become a natural part of your weekly schedule.

Get Started with BYDUREON

To understand what to expect from BYDUREON, it may be helpful to know how it works:

  • When you start BYDUREON, each weekly dose provides a gradual increase in the amount of exenatide in your blood as it is released from the microspheres (tiny particles)
  • It takes 6-7 weeks for the amount of exenatide in your blood to reach the optimal level to work in your body, or what is known as the steady state. After that, the level of exenatide is maintained with continued once-weekly injections
  • Sometimes patients can get a little bump (nodule) under their skin related to the microspheres. When it happens, it usually disappears within an average of 4 weeks
  • Serious injection-site reactions, with or without bumps, have happened in some people who use BYDUREON. Read more in the Important Safety Information below
  • You may experience some side effects. Some of the most common side effects with BYDUREON include nausea, diarrhea, headache, vomiting, constipation, itching at the injection site, a small bump (nodule) at the injection site, and indigestion
  • These are not all the side effects of BYDUREON. Talk to your doctor or other healthcare provider about any side effects that bother you or do not go away

BYDUREON SLOWLY RELEASES MEDICINE ALL WEEK LONG

BYDUREON slowly releases medicine all week long BYDUREON slowly releases medicine all week long

Illustration of a microsphere dissolving gradually releasing medicine over time.

Because it can take 6 to 7 weeks for the active ingredient in BYDUREON to reach the optimal level to work in your body, it’s important to continue using BYDUREON as prescribed by your doctor.

How BYDUREON helps to manage your blood sugar:

  • Helps your body to release insulin when needed
  • Prevents your liver from making too much sugar when it is not needed
  • Slows down how quickly the stomach digests food, to send sugar into the blood more slowly

TALK TO YOUR DOCTOR ABOUT BYDUREON

See if adding BYDUREON to your type 2 diabetes management plan is right for you.

Learn More Get the Most Out of Your Next Doctor’s Visit

BYDUREON SIDE EFFECTS

Learn about possible side effects of BYDUREON.

Learn More

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

  • POSSIBLE THYROID TUMORS, INCLUDING CANCER: Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In animal studies, BYDUREON and medicines that work like it caused thyroid tumors, including thyroid cancer. It is not known if BYDUREON will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

  • Do not use BYDUREON if you or any of your family members have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

  • Do not use BYDUREON if you have had an allergic reaction to exenatide or any of the other ingredients in BYDUREON.

BYDUREON may cause serious side effects, including:

  • Inflammation of the pancreas (pancreatitis). Stop using BYDUREON and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back

  • Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use BYDUREON with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness, or feeling jittery

  • Kidney problems (kidney failure). Tell your healthcare provider if you have or had kidney problems. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse

  • Stomach problems. Tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach (gastroparesis) or problems digesting food. Other medicines like BYDUREON may cause severe stomach problems. It is not known if BYDUREON causes or worsens stomach problems

  • Serious allergic reactions. Stop using BYDUREON and get medical help right away if you have any symptoms of a serious allergic reaction, including itching, rash, or difficulty breathing

  • Injection-site reactions. Serious injection-site reactions, with or without bumps (nodules), have happened in some people who use BYDUREON. Some of these injection-site reactions have required surgery. Call your healthcare provider if you have any symptoms of injection-site reactions, including severe pain, swelling, blisters, an open wound, or a dark scab

The most common side effects with BYDUREON may include nausea, diarrhea, headache, vomiting, constipation, itching at the injection site, a small bump (nodule) at the injection site, and indigestion. Nausea is most common when you first start using BYDUREON, but decreases over time in most people as their body gets used to the medicine.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, as taking them with BYDUREON may affect how each medicine works.

Before using BYDUREON, talk to your healthcare provider about low blood sugar and how to manage it. Tell your healthcare provider if you are taking other diabetes medicines, including insulin or sulfonylureas.

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYDUREON will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.

APPROVED USES for BYDUREON

BYDUREON is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise.

BYDUREON is not recommended as the first choice of medicine for treating diabetes.

BYDUREON is not a substitute for insulin and is not for people with type 1 diabetes or people with diabetic ketoacidosis.

BYDUREON is a long-acting form of the medication in BYETTA® (exenatide) injection so both drugs should not be used at the same time.

It is not known if BYDUREON can be used in people with a history of pancreatitis or if BYDUREON is safe and effective for use in children.

Please click here for Medication Guide, and click here for Full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.