AstraZeneca is committed to providing resources for our patients, their loved ones and the healthcare professionals caring for them during these uncertain times. Click here for our COVID-19 resource page.

US-39264 Last Updated 4/20
BYDUREON BCise® Device
BYDUREON BCise® Device

Used along with diet and exercise for adults with type 2 diabetes who are not at goal with metformin

How to use

BYDUREON BCise® is designed for simplicity

Most people—in fact 85% who were part of a study—agreed that once-weekly BYDUREON BCise is easy or very easy to use.

It’s a non-insulin medicine in an injectable device holding just one dose. You won’t have to increase your dose and there’s no need to adjust a dial (no dose dialing). Plus, the hidden needle is already attached for you.

About the medicine and the BYDUREON BCise device

Just one weekly dose of BYDUREON BCise works 7 days to help lower your blood sugar.What day will be your dosing day?

BCise dosing days Sunday through Saturday arrow
BCise dosing days Sunday through Saturday arrow

Dosing Day

*After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.

  • BYDUREON BCise can be used with or without food
  • BYDUREON BCise comes in a box containing a 4-week supply, as well as the full Instructions for Use
  • BYDUREON BCise should be stored flat in the refrigerator
  • Worried about travel plans? BYDUREON BCise may be kept at room temperature for up to 4 weeks, so you can take it with you when you need to
BYDUREON BCise device with features

A few simple steps—once a week

Simply mix, unlock, unscrew the cap, and push against skin to inject*—the device does the rest to complete the dose.

  • Step one: shake the device to mix


    Do not unlock the device yet. With the orange cap pointing up, shake the device up and down hard for at least 15 seconds. It must be evenly mixed to get the full dose.

  • Step two: twist the device to unlock


    Continue to hold the device upright. Turn the knob from the "Lock" position to the "Unlock" position. You will hear a "click".

  • Step 3: Unscrew the cap


    As you hold the device straight up, unscrew the orange cap in a counterclockwise direction. Do not pull.

  • Step 4: Inject into thigh


    Push the device firmly against your skin. You will hear a click when the injection begins. Keep the device pressed against your skin for 15 seconds to make sure you get the full dose. You can inject into your stomach, thigh, or back of the upper arm.

*Following preparation.

Please see the full Instructions for Use for complete instructions as well as the Medication Guide.

Disposal of your device: Put your used autoinjector in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose needles and syringes into your household trash.


How to inject BYDUREON BCise

Watch this instructional video.

Before you use the device for the first time, please read the full Instructions for Use to feel extra confident.

Mira este video en español.

BYDUREON BCise Nurse Support
BYDUREON BCise Nurse Support

Nurse injection help when you need it

Have questions about how to use BYDUREON BCise? Or injecting for the first time? Feel free to talk or video chat with one of our BYDUREON BCise nurses for the support you need.

You can speak to a nurse by calling 

1-844-MY-BCISE (1-844-692-2473) 

8 AM – 8 PM ET, Monday – Friday 

and 10 AM – 6 PM, Saturday and Sunday*

*AstraZeneca cannot provide medical advice and can only provide information about AstraZeneca medications. Decisions regarding your health and treatment of your condition should be made with your own healthcare provider.
BYDUREON BCise Savings Card
BYDUREON BCise Savings Card

Sign up for savings and support comes with it

*Most commercially insured patients are eligible for a $0 co-pay for as long as your doctor prescribes BYDUREON BCise. See eligibility requirementsRestrictions apply. Not available for government-insured patients.


BYDUREON BCise may cause serious side effects, including:

  • POSSIBLE THYROID TUMORS, INCLUDING CANCER Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In animal studies, BYDUREON and medicines that work like it caused thyroid tumors, including thyroid cancer. It is not known if BYDUREON BCise will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
  • Do not use BYDUREON BCise if you or any of your family members have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • Do not use BYDUREON BCise if you have a history of low blood platelet count from using exenatide medicines (drug-induced thrombocytopenia)
  • Do not use BYDUREON BCise if you have had an allergic reaction to exenatide or any of the other ingredients in BYDUREON BCise
  • Inflammation of the pancreas (pancreatitis) Stop using BYDUREON BCise and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
  • Low blood sugar (hypoglycemia) Your risk for getting low blood sugar may be higher if you use BYDUREON BCise with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Tell your healthcare provider if you take other diabetes medicines. Talk to your healthcare provider about managing low blood sugar. Signs and symptoms of low blood sugar include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness, or feeling jittery
  • Kidney problems Tell your healthcare provider if you have or had kidney problems. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse or kidney failure
  • Stomach problems Tell your healthcare provider if you have severe stomach problems, such as slowed emptying of your stomach (gastroparesis) or problems digesting food. Other medicines like BYDUREON BCise may cause severe stomach problems. It is not known if BYDUREON BCise causes or worsens stomach problems
  • Low blood platelet count BYDUREON BCise may cause the number of platelets in your blood to be reduced. When your platelet count is too low, your body cannot form blood clots. You could have serious bleeding that could lead to death. Stop using BYDUREON BCise and call your healthcare provider right away if you have unusual bleeding or bruising
  • Serious allergic reactions Stop using BYDUREON BCise and get medical help right away if you have any symptoms of a serious allergic reaction, including itching, rash, or difficulty breathing
  • Injection-site reactions Serious injection-site reactions, with or without bumps (nodules), have happened in some people who use BYDUREON BCise. Some of these injection-site reactions have required surgery. Call your healthcare provider if you have any symptoms of injection-site reactions, including severe pain, swelling, blisters, an open wound, or a dark scab
  • Gallbladder problems have happened in some people who take BYDUREON or other medicines like it. Tell your healthcare provider right away if you get symptoms of gallbladder problems including pain in the right or middle upper stomach area, nausea and vomiting, fever, or your skin or the white part of your eyes turns yellow

The most common side effects with BYDUREON BCise may include a bump at the injection site and/or nausea. Nausea is most common when you first start using BYDUREON BCise, but decreases over time in most people as their body gets used to the medicine.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, as taking them with BYDUREON BCise may affect how each medicine works.

Before using BYDUREON BCise, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant or nurse. BYDUREON BCise may harm your unborn baby.


  • BYDUREON BCise is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise
  • BYDUREON BCise is not recommended as the first choice of medicine for treating diabetes
  • BYDUREON BCise is not for people with type 1 diabetes
  • Do not use BYDUREON, BYDUREON BCise, BYETTA or other medicines containing exenatide together
  • It is not known if BYDUREON BCise can be used in people with a history of pancreatitis 

Please click here for Medication Guide, and click here for Full Prescribing Information for BYDUREON BCise.

You may report side effects related to AstraZeneca products by clicking here.

Approved Uses and Important Safety Information


Read More