To help lower blood sugar, along with diet and exercise, in adults with type 2 diabetes who are not at goal with oral diabetes medications

Used along with diet and exercise for adults on oral type 2 diabetes medicine(s) who are still trying to reach their A1C goal

sayhelloSun icon

to an option that may help provide consistent control of your blood sugar—BYDUREON BCise®

After 10 weeks of continued once-weekly dosing, BYDUREON BCise is ready to work when you need it, keeping a consistent level of medicine in your body, working for you 7 days a week.

One dose. Once a week. Lasts all week.*

As you keep up with your hectic life, it’s important to keep in mind that type 2 diabetes can progress over time. So, you may need a different approach to your treatment to help manage blood sugar highs and lows—and reach your A1C goal.

BYDUREON BCise® is a non-insulin, once-a-week injectable that works all week long.* Along with diet and exercise, it has been proven to significantly lower A1C.

Here are some of the key benefits of BYDUREON BCise:

  • Non-insulin injectable iconNon-insulin injectable
  • A1C effect iconReduced up to 1.4%
  • Weight effect iconWeight reduced up to 3 lbNot a weight-loss drug.
  • Cardiovascular safety iconCardiovascular-safe

In 2 clinical studies lasting 28 weeks, BYDUREON BCise lowered A1C by an average of 1.1% and 1.4% from an average starting A1C of 8.4% and 8.5%, respectively, when used alone or with certain oral type 2 diabetes medicine(s). Your results may vary

In the same studies, BYDUREON BCise lowered weight by an average of 3 lb from average starting weights of 196 and 213 lb. BYDUREON BCise is not a weight-loss drug

In another clinical study, including patients with and without established cardiovascular disease, it was proven that BYDUREON does not increase the risk of major cardiovascular events like heart attack, stroke or cardiovascular death. BYDUREON BCise is not approved to reduce the risk of CV events or death

*After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.

EXenatide Study of Cardiovascular Event Lowering Trial (EXSCEL) evaluated cardiovascular outcomes after patients were treated with BYDUREON®, another formulation of exenatide extended-release.

Most common side effects

The most common side effects with BYDUREON BCise® include a bump at the injection site and nausea. Other side effects that occur less often include headache, diarrhea, vomiting, injection-site itching and redness, dizziness, and constipation. Serious injection-site reactions have happened in some people who use BYDUREON. These are not all the possible side effects of BYDUREON BCise. See the Important Safety Information below for more information and talk to your healthcare provider if you have any side effects that bother you or do not go away.

Video still of animated woman preparing a salad.

See The Inside Story : How BYDUREON BCise® may help give you consistent control of your blood sugar*

BYDUREON BCise is slowly released into your body—over time—through an extended-release delivery system. See for yourself how it’s ready to work when you need it to help lower your blood sugar.*

*Following 10 weeks of once-weekly dosing when the level of medicine in your body
should be at the optimal level.

Therapeutic levels overtime graph Therapeutic levels overtime graph

Levels gradually build over time

This graph is a simplified representation of how the levels of medicine in your blood may not represent actual changes in your blood sugar.

How BYDUREON BCise® builds to its optimal level

BYDUREON BCise releases the medicine gradually and continually over time. With each weekly dose, the amount of medicine in your body builds up until it reaches an optimal level after 10 weeks, to help give you consistent control of your blood sugar 7 days a week.

Human body highlighting liver, stomach, and pancreas.

BYDUREON BCise® is ready to work with your body when you need it*

BYDUREON BCise is a type 2 diabetes medicine that is slowly released into your body over time, working to help your body release its own insulin when it’s needed to help lower blood sugar.

Liver

With type 2 diabetes, a hormone called glucagon causes the liver to make sugar when it's not needed. BYDUREON BCise mimics the actions of GLP-1, a natural hormone, to help prevent the release of glucagon.

Stomach

With type 2 diabetes, the stomach moves food along faster than it should, and that sends sugar into the blood faster. BYDUREON BCise works to slow down how quickly the stomach empties sending sugar into the blood stream more slowly.

Pancreas

With type 2 diabetes, too little insulin is produced by the pancreas to keep blood sugar levels normal. BYDUREON BCise mimics the GLP-1 hormone to help your pancreas release insulin when blood sugar needs to go down.*

See The Inside Story   video and learn how BYDUREON BCise works with your body.

*After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.

  • Stethoscope icon

A little help to prepare you for your next doctor’s appointment

While type 2 diabetes may not be easy to manage, talking to your doctor should be.

Want help for your discussion?

Read each statement and choose the answer that best describes you.

  • I’m frustrated with my blood sugar highs and lows.
  • I feel I’m doing my best—diet, exercise, medicine—but I’m still not meeting my A1C goal.
  • I feel uneasy about talking to my doctor about other treatment options.

Your answers can help direct the conversation. Bring this guide to your next doctor's visit and ask if BYDUREON BCise® is an option for you.

  • Check mark icon

    If you’re frustrated with your blood sugar highs and lows, ask your doctor if BYDUREON BCise, along with diet and exercise, could help give you consistent control of your blood sugar.

  • Check mark icon

    Doing your best to manage type 2 diabetes is not easy, but it’s important. Along with diet and exercise, BYDUREON BCise has been proven to significantly lower A1C. And although it’s not a weight-loss drug, BYDUREON BCise may help you lose some weight.

    • In 2 clinical studies lasting 28 weeks, BYDUREON BCise lowered A1C by an average of 1.1% to 1.4% from an average starting A1C of 8.4% to 8.5%, respectively, when used alone or with certain oral type 2 diabetes medicines(s). Your results may vary

    • In the same studies, BYDUREON BCise lowered weight by an average of 3 lb from average starting weights of 196 and 213 lb. Your results may vary. BYDUREON BCise is not a weight-loss drug

    • The most common side effects were a bump at the injection site and nausea.

  • Check mark icon

    Over time, type 2 diabetes may progress, leaving you feeling frustrated about getting to your A1C goal. It’s normal to feel uneasy about starting a conversation with your doctor. So, use these talking points as your guide, and make a list of concerns about your current treatment plan before your visit.

  • Thumbs up confirmation icon

It still may be a good time to talk with your doctor about your type 2 diabetes treatment plan

Even if you feel you are staying on track, let your doctor know. These are the types of discussions doctors want to hear about, too.

Bydureon BCise device

Could BYDUREON BCise® fit into my life?

Trying to manage a busy life and type 2 diabetes? Still working to get your blood sugar under control? This may not be easy. Once-weekly BYDUREON BCise may help provide consistent control of your blood sugar.*

If you’re worried that your current medication isn’t doing enough to manage your A1C, ask your doctor about BYDUREON BCise. In the meantime, see if these statements ring true to you.

*After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.

Read the following statements. Then, select the answers that apply to you.

  • I’m frustrated with my blood sugar highs and lows.
  • I’m tired of taking pills every day.
  • I feel I’m doing my best—diet, exercise, medicine—but I’m still not meeting my A1C goal.

Is this an opportunity to talk with your doctor about whether BYDUREON BCise could fit into your life?

  • Check mark icon

    If you’re frustrated with your blood sugar highs and lows…Watch this video to learn how BYDUREON BCise works differently to help give you consistent control of your blood sugar.*

    *After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.
  • Check mark icon

    If you’re frustrated trying to manage type 2 diabetes—including taking oral diabetes medications every day… Learn more about BYDUREON BCise. One dose. Once a week. Lasts all week.*

    *After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.
  • Check mark icon

    If you’re not meeting your A1C goal even though you feel like you’re doing your best…Perhaps it’s time to talk to your doctor, and ask whether BYDUREON BCise could be right for you.

  • Thumbs up confirmation icon

Stay on track!

Managing type 2 diabetes may not be easy. Stay motivated with food and fitness hacks that could help simplify things. Sign up for the type of support that fits you.

You have questions. We have answers.

Some of the most commonly asked questions about BYDUREON BCise®.

What is the most important information I should know about BYDUREON BCise?

BYDUREON BCise may cause serious side effects, including:

POSSIBLE THYROID TUMORS, INCLUDING CANCER: Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In animal studies, BYDUREON and medicines that work like it caused thyroid tumors, including thyroid cancer. It is not known if BYDUREON BCise will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

Do not use BYDUREON BCise if you or any of your family members have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

See additional Important Safety Information.

How can BYDUREON BCise help me?

BYDUREON BCise has been proven to help significantly lower A1C along with diet and exercise. Also, although not a weight-loss drug, BYDUREON BCise may help you lose some weight.

In one clinical study lasting 28 weeks, BYDUREON BCise lowered A1C by an average of 1.4% from an average starting A1C of 8.5% and lowered weight by an average of 3 lb from an average starting weight of 213 lb when used alone or with certain oral type 2 diabetes medicine(s). In a second clinical study, BYDUREON BCise lowered A1C by an average of 1.1% from an average starting A1C of 8.4% and lowered weight by an average of 3 lb after 28 weeks from an average starting weight of 196 lb when added to metformin. Your results may vary.

How does one dose of BYDUREON BCise work 7 days?

BYDUREON BCise has convenient once-weekly dosing and an extended-release delivery system. Each dose contains tiny beads that slowly dissolve to continuously release medicine into your body over time, helping your body release its own insulin, when needed, to help lower blood sugar.

After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.

How long does it take for BYDUREON BCise to lower my blood sugar?

BYDUREON BCise works gradually and continually. As you continue to take your weekly doses, the amount of medicine in your body gradually builds up over 10 weeks until it reaches an optimal level to work in your body. With continued once-weekly dosing, the extended-release delivery system of BYDUREON BCise keeps a consistent level of medicine in your body, ready to work when you need it to help lower your blood sugar.

Remember, you need to continue to take BYDUREON BCise exactly as your doctor or healthcare provider has prescribed it, along with continuing to follow the treatment plan they’ve recommended.

Bydureon BCise savings card

Could you lower your prescription cost to $0 a month?

Save on your prescription—consistently

Pay as low as $0 every month with your prescription for BYDUREON BCise®.* Offer subject to Savings Eligibility Requirements and Program Terms of Use.

When you download your savings card, you can sign up for customized patient support, including helpful tips and dosing reminders sent right to your email or through a text message.

*See eligibility requirements. Restrictions apply.
Register now
 
CLOSE  

Approved Uses and Important Safety Information
WARNING: POSSIBLE RISK OF THYROID TUMORS INCLUDING THYROID CANCER Read Morearrow image

IMPORTANT SAFETY INFORMATION

BYDUREON® (exenatide extended-release) and BYDUREON BCise may cause serious side effects, including:

  • POSSIBLE THYROID TUMORS, INCLUDING CANCER Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In animal studies, BYDUREON and medicines that work like it caused thyroid tumors, including thyroid cancer. It is not known if BYDUREON or BYDUREON BCise will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
  • Do not use BYDUREON or BYDUREON BCise if you or any of your family members have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • Do not use BYDUREON or BYDUREON BCise if you have had an allergic reaction to exenatide or any of the other ingredients in BYDUREON or BYDUREON BCise
  • Inflammation of the pancreas (pancreatitis) Stop using BYDUREON or BYDUREON BCise and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
  • Low blood sugar (hypoglycemia) Your risk for getting low blood sugar may be higher if you use BYDUREON or BYDUREON BCise with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Tell your healthcare provider if you take other diabetes medicines. Talk to your healthcare provider about managing low blood sugar. Signs and symptoms of low blood sugar include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness, or feeling jittery
  • Kidney problems Tell your healthcare provider if you have or had kidney problems. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse or kidney failure
  • Stomach problems Tell your healthcare provider if you have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food. Other medicines like BYDUREON and BYDUREON BCise may cause severe stomach problems. It is not known if BYDUREON or BYDUREON BCise cause or worsen stomach problems
  • Serious allergic reactions Stop using BYDUREON or BYDUREON BCise and get medical help right away if you have any symptoms of a serious allergic reaction, including itching, rash, or difficulty breathing
  • Injection-site reactions Serious injection-site reactions, with or without bumps (nodules), have happened in some people who use BYDUREON. Some of these injection-site reactions have required surgery. Call your healthcare provider if you have any symptoms of injection-site reactions, including severe pain, swelling, blisters, an open wound, or a dark scab
  • Gallbladder problems have happened in some people who take BYDUREON or other medicines like it. Tell your healthcare provider right away if you get symptoms of gallbladder problems including pain in the right or middle upper stomach area, nausea and vomiting, fever, or your skin or the white part of your eyes turns yellow

The most common side effects with BYDUREON may include nausea, diarrhea, headache, vomiting, constipation, itching at the injection site, a small bump (nodule) at the injection site, and indigestion.

The most common side effects with BYDUREON BCise may include a bump at the injection site and/or nausea. Nausea is most common when you first start using BYDUREON or BYDUREON BCise, but decreases over time in most people as their body gets used to the medicine.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, as taking them with BYDUREON or BYDUREON BCise may affect how each medicine works.

Before using BYDUREON or BYDUREON BCise, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant or nurse. BYDUREON or BYDUREON BCise may harm your unborn baby.

APPROVED USES

  • BYDUREON and BYDUREON BCise are both injectable prescription medicines that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise
  • BYDUREON and BYDUREON BCise are not recommended as the first choice of medicine for treating diabetes
  • BYDUREON and BYDUREON BCise are not substitutes for insulin and are not for people with type 1 diabetes or people with diabetic ketoacidosis
  • It is not known if BYDUREON can be used with mealtime insulin or if BYDUREON BCise can be used with insulin
  • Do not use BYDUREON, BYDUREON BCise, BYETTA or other medicines containing exenatide together
  • It is not known if BYDUREON or BYDUREON BCise can be used in people with a history of pancreatitis

Please click here for Medication Guide, and click here for Full Prescribing Information for BYDUREON BCise.

Please click here for Medication Guide, and click here for Full Prescribing Information for BYDUREON Pen.

You may report side effects related to AstraZeneca products by clicking here.

APPROVED USES

  • BYDUREON and BYDUREON BCise are both injectable prescription medicines that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise
  • BYDUREON and BYDUREON BCise are not recommended as the first choice of medicine for treating diabetes
  • BYDUREON and BYDUREON BCise are not substitutes for insulin and are not for people with type 1 diabetes or people with diabetic ketoacidosis
  • It is not known if BYDUREON can be used with mealtime insulin or if BYDUREON BCise can be used with insulin
  • Do not use BYDUREON, BYDUREON BCise, BYETTA or other medicines containing exenatide together
  • It is not known if BYDUREON or BYDUREON BCise can be used in people with a history of pancreatitis