To help lower blood sugar, along with diet and exercise, in adults with type 2 diabetes who are not at goal with oral diabetes medications

What Is Type 2 Diabetes?

Type 2 diabetes—also known as adult-onset or non–insulin-dependent diabetes—is a chronic and progressive condition that affects the way your body controls the amount of sugar (glucose) in the blood.

What causes type 2 diabetes?

Type 2 diabetes can be caused by changes in multiple organs and hormones in the body. Over time, these changes may lead to high sugar (glucose) levels. Insulin is a hormone that transfers glucose from the blood into cells to produce the energy needed for daily activities. In people who have type 2 diabetes, insulin can’t do its job. That’s because too little insulin is produced to keep glucose levels normal, or the body fails to respond to it.

As part of this condition, other hormones which help control the amount of glucose appearing in or being transferred from the blood also don’t work the right way. This causes blood glucose levels to go up. These high glucose levels can get worse because the body increases the amount of glucose that is produced, and the excess glucose is recirculated into the blood.

What is A1C?

A1C is a measure of your average blood sugar (blood glucose) control for the past 2 to 3 months and is likely one of the tests your healthcare provider used to help diagnose you with type 2 diabetes.

The A1C test measures the amount of glucose that enters red blood cells and links up with a protein called hemoglobin, which is proportional to the amount of glucose in the blood. The results are given as a percentage. The lower your A1C level, the better your blood sugar control has been over the past 2 to 3 months.

In addition to helping your healthcare provider diagnose type 2 diabetes, A1C tests can help manage your type 2 diabetes by:

  • Confirming self-testing results or blood test results at the doctor’s office
  • Helping your doctor decide whether a treatment plan is working for you
  • Showing you how healthy diet and exercise choices can make a difference in diabetes control

As shown below, different A1C levels are associated with different stages of the disease.


A1C under 5.7%


A1C between 5.7% and 6.4%


A1C of 6.5% or higher

If your A1C is 6.5% or higher and you have been diagnosed with type 2 diabetes, your doctor may have prescribed one or more medications to help you lower your blood sugar.

What should your A1C be?

For most adults with type 2 diabetes, an A1C goal of less than 7% may be appropriate. However, your healthcare provider may set a different goal for you based on your own personal needs and medical history. If you are unsure, ask your healthcare provider what your personal A1C goal should be.

How to lower blood sugar

If you have been diagnosed with type 2 diabetes, your doctor will work with you to put together a treatment plan for lowering your blood sugar. This may include lifestyle changes such as eating a healthy diet and exercising.

In addition to these lifestyle changes, your doctor may prescribe medications that can help you lower your blood sugar. It’s important to take your medications exactly as your doctor prescribes.


BYDUREON BCise is a once-weekly treatment that uses a unique delivery system.

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Talk to Your Doctor About BYDUREON BCise

See if adding BYDUREON BCise to your type 2 diabetes management plan is right for you.

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BYDUREON BCise may cause serious side effects, including:

  • POSSIBLE THYROID TUMORS, INCLUDING CANCER Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In animal studies, BYDUREON and medicines that work like it caused thyroid tumors, including thyroid cancer. It is not known if BYDUREON BCise will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

  • Do not use BYDUREON BCise if you or any of your family members have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

  • Do not use BYDUREON BCise if you have had an allergic reaction to exenatide or any of the other ingredients in BYDUREON BCise

  • Inflammation of the pancreas (pancreatitis) Stop using BYDUREON BCise and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back

  • Low blood sugar (hypoglycemia) Your risk for getting low blood sugar may be higher if you use BYDUREON BCise with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Tell your healthcare provider if you take other diabetes medicines. Talk to your healthcare provider about managing low blood sugar. Signs and symptoms of low blood sugar include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness, or feeling jittery

  • Kidney problems (kidney failure) Tell your healthcare provider if you have or had kidney problems. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse

  • Stomach problems Tell your healthcare provider if you have severe stomach problems, such as slowed emptying of your stomach (gastroparesis) or problems digesting food. Other medicines like BYDUREON BCise may cause severe stomach problems. It is not known if BYDUREON BCise causes or worsens stomach problems

  • Serious allergic reactions Stop using BYDUREON BCise and get medical help right away if you have any symptoms of a serious allergic reaction, including itching, rash, or difficulty breathing

  • Injection-site reactions Serious injection-site reactions, with or without bumps (nodules), have happened in some people who use BYDUREON BCise. Some of these injection-site reactions have required surgery. Call your healthcare provider if you have any symptoms of injection-site reactions, including severe pain, swelling, blisters, an open wound, or a dark scab

The most common side effects with BYDUREON BCise may include a bump at the injection site and/or nausea. Nausea is most common when you first start using BYDUREON BCise, but decreases over time in most people as their body gets used to the medicine.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, as taking them with BYDUREON BCise may affect how each medicine works.

Before using BYDUREON BCise, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant or nurse. BYDUREON BCise may harm your unborn baby.


  • BYDUREON BCise is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise

  • BYDUREON BCise is not recommended as the first choice of medicine for treating diabetes

  • BYDUREON BCise is not a substitute for insulin and is not for people with type 1 diabetes or people with diabetic ketoacidosis

  • Do not use BYDUREON, BYDUREON BCise, BYETTA or other medicines containing exenatide together

  • It is not known if BYDUREON BCise can be used in people with a history of pancreatitis

Please click here for Medication Guide, and click here for Full Prescribing Information.

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