How Does BYDUREON BCise Work?

BYDUREON BCise is a prescription treatment used along with diet and exercise to help improve blood sugar in adults with type 2 diabetes who are not controlled on one or more oral diabetes medications. It has convenient once-weekly dosing and an extended-release delivery system. Each dose contains tiny beads that slowly dissolve to continuously release medicine into your body over time, helping your body release its own insulin, when needed, to help lower blood sugar.

BYDUREON BCise slowly releases medicine over time.

Learn about how BYDUREON BCise works

Illustration of a tiny bead dissolving gradually, releasing medicine over time.

BYDUREON builds up over 10 weeks.

This graph is a simplified representation of how the medicine builds up in your body, and the levels of medicine in your blood may not represent actual changes in your blood sugar.

As you continue to take your weekly doses, the amount of medicine in your body gradually builds up over 10 weeks until it reaches an optimal level to work in your body. With continued once-weekly dosing, the extended release delivery system of BYDUREON BCise keeps a consistent level of medicine in your body, ready to work when you need it to help lower your blood sugar.

After 10 weeks of continued once-weekly dosing, BYDUREON BCise keeps a consistent level of medicine in your body, working for you 7 days a week.


Use BYDUREON BCise one time each week on the same day that fits your schedule at any time of the day.

Is BYDUREON BCise Insulin?

BYDUREON BCise is not insulin; it is a type 2 diabetes medicine that is slowly released into your body over time, working to help your body release its own insulin when it’s needed to lower blood sugar. This helps lower your blood sugar when you need it.

For people with type 2 diabetes, certain things can contribute to high blood sugar:

  • Too little insulin is produced by the pancreas to keep sugar levels normal, or the body fails to respond to it

  • A natural hormone causes the liver to make sugar when more sugar is not needed

  • The stomach moves food along faster than it should, sending sugar into the blood faster

BYDUREON BCise works with your body to:

BYDUREON BCise works with your body to combat certain things contributing to high blood sugar.

Learn How to Use the Device

Find out more about the BYDUREON BCise device and how to use it.

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BCise side effects

BYDUREON BCise Side Effects

Learn about possible side effects of BYDUREON BCise.

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BYDUREON BCise may cause serious side effects, including:

  • POSSIBLE THYROID TUMORS, INCLUDING CANCER Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In animal studies, BYDUREON and medicines that work like it caused thyroid tumors, including thyroid cancer. It is not known if BYDUREON BCise will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

  • Do not use BYDUREON BCise if you or any of your family members have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

  • Do not use BYDUREON BCise if you have had an allergic reaction to exenatide or any of the other ingredients in BYDUREON BCise

  • Inflammation of the pancreas (pancreatitis) Stop using BYDUREON BCise and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back

  • Low blood sugar (hypoglycemia) Your risk for getting low blood sugar may be higher if you use BYDUREON BCise with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Tell your healthcare provider if you take other diabetes medicines. Talk to your healthcare provider about managing low blood sugar. Signs and symptoms of low blood sugar include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness, or feeling jittery

  • Kidney problems (kidney failure) Tell your healthcare provider if you have or had kidney problems. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse

  • Stomach problems Tell your healthcare provider if you have severe stomach problems, such as slowed emptying of your stomach (gastroparesis) or problems digesting food. Other medicines like BYDUREON BCise may cause severe stomach problems. It is not known if BYDUREON BCise causes or worsens stomach problems

  • Serious allergic reactions Stop using BYDUREON BCise and get medical help right away if you have any symptoms of a serious allergic reaction, including itching, rash, or difficulty breathing

  • Injection-site reactions Serious injection-site reactions, with or without bumps (nodules), have happened in some people who use BYDUREON. Some of these injection-site reactions have required surgery. Call your healthcare provider if you have any symptoms of injection-site reactions, including severe pain, swelling, blisters, an open wound, or a dark scab

The most common side effects with BYDUREON BCise may include a bump at the injection site and/or nausea. Nausea is most common when you first start using BYDUREON BCise, but decreases over time in most people as their body gets used to the medicine.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, as taking them with BYDUREON may affect how each medicine works.

Before using BYDUREON BCise, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant or nurse. BYDUREON BCise may harm your unborn baby.


  • BYDUREON BCise is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes mellitus, and should be used along with diet and exercise

  • BYDUREON BCise is not recommended as the first choice of medicine for treating diabetes

  • BYDUREON BCise is not a substitute for insulin and is not for people with type 1 diabetes or people with diabetic ketoacidosis

  • Do not use BYDUREON, BYDUREON BCise, BYETTA or other medicines containing exenatide together

  • It is not known if BYDUREON BCise can be used in people with a history of pancreatitis

Please click here for Medication Guide, and click here for Full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.